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KMID : 1137820170380010049
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의공학회지
2017 Volume.38 No. 1 p.49 ~ p.55
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The Effects of Whole Body Vibration in the Aspect of Reducing Abdominal Adipose Tissue in High-Fat Diet Mice Model
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Hwang Dong-Hyun
Kim Seo-Hyun
Lee Han-A
Lee Sang-Yeob
Seo Dong-Hyeon
Cho Seung-Kwan
Chen Seul-Gi
Han Tae-Young
Kim Han-Sung
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Abstract
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The prevalence of obesity has noticeably increased worldwide over several decades with various complication. Even though anti-obesity drug treatments have been spotlighted by resulting in effective mean weight losses, its adverse effects cannot be overlooked. Thus, this study aimed to evaluate the effects of multi-frequency whole body vibration, one of the mechanical stimulus, as a countermeasure against obesity. Thirty-two-6-week-old C57BL/6J male mice were equally assigned to four groups: the Control group (CON, n = 8), the Sham group (Sham, n = 8), the sham with single frequency whole body vibration (S+V, n = 8), and the sham with multi frequency whole body vibration (S+MV, n = 8). After 4 weeks, morphologic changes in the adipose tissue were evaluated from three-dimensional images using in vivo micro-computed tomography. At 4 weeks, the volume of the abdominal adipose tissue, which had the highest value in Sham group, noticeably reduced in S+MV group compared to it in S+V group. These results implied that the accumulation of abdominal adipose tissue can be effectively reduced through applying multi-frequency whole body vibration.
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KEYWORD
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Obese, Whole-Body Vibration, Abdominal tissue, Micro-CT, Threshold analysis
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